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Product name: L-theanine
Synonyms: Theanine,98%; L-Theanine; N5-Ethyl-L-glutamine; L- theanine; N-ethyl-L-glutamine
CAS number: 3081-61-6
Molecular Formula: C7H14N2O3
Molecular Weight: 174.1977
Specifications: 99%
Appearance/color: white fine powder
Benefits: promote sleep, anti-anxiety
Application: food, medicine, food supplement
Dosage: 100-250mg per day
Bulk Package: 25kgs/drum

1. What is L-theanine?

L-theanine is also known as glutamylethylamine, English name is L-Theanine, Cas number: 3081-61-6, molecular formula: C7H14N2O3, is an amide compound, white or off-white powder, melting point 214-215 degrees , It is easily soluble in water, has a caramel aroma and a refreshing taste similar to MSG.

L-theanine is only found in tea-producing plants in nature, accounting for between 1% and 2% of the dry weight of tea. It exists in a free form and is the main amino acid in tea, accounting for all free amino acids. Around 50%. Theanine is necessary for the human body, but it cannot be synthesized in the human body and depends on external supply.

Since ancient times, people believed that drinking tea can relax people’s emotions. In fact, it is the theanine in tea that plays a role. Theanine not only gives the tea a fragrance, but also has a significant relaxing effect. In today’s society, everyone is under various mental pressures, and theanine can make people feel relaxed.

2. Source of L-theanine.

theanine is a natural product found in green tea. It can also be obtained by high-pressure heating of L-glutamic acid into pyrrolidone carboxylic acid, adding anhydrous monoethylamine and high-pressure heating.

MR Natural L-theanine is made from L-glutamic acid.

3. Basic physical and chemical properties of L-theanine

Specification  Standard(JP2000) Test Method
Appearance White crystalline powder Seeing
Assay 98.0-102.0% HPLC
Specific rotation(a)D20 (C=1 , H2O ) +7.7 to +8.5 DegreeCP2015
Solubility (1.0g/20ml H2O)Clear Colorless Seeing
Chloride(C1) ≤ 0.02% CP2015
Loss on drying≤  0.5%CP2015
Residue on ignition ≤ 0.2% CP2015
Melting point202-215℃CP2015       
Heavy metals(as Pb )≤10ppm CP2015
Arsenic(as As ) 1ppm CP2015
Total Plate Count<1000cfu/gCP2015
Mold And Yeasts<100cfu/gCP2015

The Product Conforms To JP2000 Standard

4. Manufacturing Flow Chart of L-theanine

L-theanine production flow chart

5. L-theanine benefits

A. The physiological role of L-theanine

Lower blood pressure: The regulation of blood pressure mainly depends on catecholamines and serotonin. L-theanine can lower the level of serotonin. Experiments in rats have confirmed that L-theanine can significantly reduce blood pressure. The higher the dose, the more obvious the reduction; while rats with normal blood pressure have no blood pressure reduction, which shows that L-theanine is only effective Rats suffering from hypertension have the effect of lowering blood pressure.

Calming effect: As we all know, tea contains caffeine with excitatory effect, but when people drink tea, they feel relaxed, tranquil and relaxed, and their excitement tends to calm down. It has been confirmed that this is mainly due to the effect of L-theanine. .

Improve learning ability: L-theanine can obviously affect the release or decrease of neurotransmitters such as dopamine and serotonin. These neurotransmitters are closely related to memory and learning ability. Therefore, it is possible to investigate the effect of L-theanine on memory and The impact of learning ability. Japanese studies have shown that L-theanine is absorbed by the intestines after being fed to mice and transported to the liver and brain through the blood. When L-theanine enters the brain, it significantly increases the neurotransmitter dopamine in the brain mitochondria, and dopamine It is the precursor of adrenaline and norepinephrine, and it is a substance that plays an important role in conveying the excitement of brain nerve cells. Animal experiments show that L-theanine has a positive effect on memory and learning ability.

Relaxation function: Generally speaking, weak brain waves are generated on the surface of the brains of animals and humans. According to their frequency, they can be divided into four types, namely α, β, δ and θ waves. Each wave is related to the individual’s mental condition. The alpha wave is related to relaxation. Some experiments have shown that after 40 minutes of absorbing L-theanine, obvious α brain waves can be detected on the surface of the brain, which indicates that L-theanine can promote the production of α brain waves and make people enter a relaxed state.

B. The application of L-theanine in food

L-theanine can be used as a food additive in beverages, biscuits, candies, ice cream and rock candy. because:

L-theanine has the effect of improving the flavor of food: cocoa drinks and barley tea have a unique bitter or spicy taste, adding sweeteners will have an unpleasant taste. Studies have shown that if 0.01% L-theanine is substituted Sweeteners and beverage flavor are greatly improved. And in other foods such as coffee, cocoa, ginseng drinks, beer, it also has a good effect of improving flavor.

L-theanine has good stability: when a beverage containing L-theanine is heated to 121°C for 5 minutes, the L-theanine in the beverage will not be degraded. At the same time, L-theanine is also very stable when the pH is between 3.0 and 6.6. Store the beverage at 25°C for one year. No matter the solution is neutral (PH6.5) or acid (PH3.0), L-theanine shows good stability.

L-theanine can promote the production of alpha waves in the brain: alpha waves can make people in a state of wakefulness, sensitivity, body and spirit relaxation. L-theanine does not increase theta wave, so adding it to various foods will not produce a feeling of drowsiness. According to the results of L-theanine’s effect on alpha waves, 50-200mg of L-theanine can produce relaxation results, and the relaxation effect on emotionally unstable people is also very significant.

At present, most of the health foods on the market are for the prevention or improvement of adult diseases. Theanine, such as theanine, which has no hypnosis, can relieve fatigue, lower blood pressure and improve learning and memory, is really rare and extremely attractive. Attention. For this reason, theanine won an award at the 1998 International Food Ingredients Conference held in Germany. According to an investigation by an authoritative department, in 2002, L-theanine took the lead among the main natural anti-cancer/immunity-enhancing health products sold in the international medical and health products market.

C. The application of L-theanine in medicine

Dr. Bukowski of Harvard Medical School and his research team recently published a research report in the Proceedings of the National Academy of Sciences. They extracted L-theanine (L-theanine) from tea products such as green tea and oolong tea. -Theanine), which can enhance the body’s immune system to resist the invasion of bacteria, viruses and fungi. They conducted experiments on volunteers and proved that this substance can increase the body’s resistance to infectious diseases by 5 times and can effectively resist the invasion of pathogenic microorganisms.

L-theanine can also promote the brain’s learning and memory functions and can prevent Parkinson’s disease, menopausal syndrome, senile dementia, conduction nerve dysfunction and other diseases. L-theanine also has a cardiotonic diuretic , Dilate blood vessels, and help prevent liver coma, memory impairment and mental retardation.

6. Dosage of L-theanine

100-250mg per day.

7. L-theanine side effects

Theanine has been used for many years, but it is rarely found to have side effects. Although people think it is a 100% safe and health care product, it is actually a misunderstanding. To some extent, there are no relevant clinical reports. But it does not mean that theanine has no side effects at all, and more research is needed to understand its impact on human health.

8. Safety of L-theanine

Theanine is sold in the United States as a dietary supplement and has been granted GRAS (generally recognized as safe) status by the Food and Drug Administration (FDA)

9. L-theanine related researches

10. L-theanine package & Notes for shipping

25kgs/drum, inner by double plastic bags.

N.W./G.W.: 25kgs/28kgs

Small order is accepted too. Such like 1kg/5kgs/10kgs.

Package for small quantity is by aluminium foil bag and carton box.

HS code: 2924199090

11. Q & A for L-theanine

Q: How quickly does L Theanine work for anxiety?

A: A calming effect is usually noted within 30 to 40 minutes after L-theanine is taken at a dose of 50 to 200mg, and typically lasts 8 to 10 hours. Moderate anxiety symptoms often improve with a regimen of 200mg once or twice daily.

Q: Does L Theanine make you happy?

A: That high L-Theanine makes us feel mentally and emotionally calmer, it helps us focus and improves retention and recall, it also increases dopamine levels so we feel happier!

Q: Can L Theanine cause more anxiety?

A: Studies show that increasing intake of theanine can significantly reduce symptoms of anxiety, such as a racing heartbeat and increased secretion of immunoglobulin A in saliva. Its effects are somewhat similar to those of a sedative, but L-theanine is far from this prescription drug.

Q: Is L Theanine good for depression?

A: Study suggests that chronic (8-week) l-theanine administration is safe and has multiple beneficial effects on depressive symptoms, anxiety, sleep disturbance and cognitive impairments in patients with MDD.

Q: Does L Theanine make you gain weight?

A: The anti-anxiety and sleep-promoting abilities of L-theanine may help people to maintain a healthy weight. After all, getting enough sleep and limiting stress are both key to sticking with a healthy diet and avoiding weight gain. L-theanine may also play a more direct role in weight maintenance.

Q: Is L Theanine bad for your liver?

A: According to a paper from Anhui Agricultural University in China, theanine can protect liver tissue, minimising damage to the liver from chronic inflammation and its resultant diseases. The amino acid was found to increase antioxidant enzyme activity in mice, and to improve the human immune system.

Q: Does L Theanine stop panic attacks?

A: The anti-anxiety effect of L-theanine is achieved through enhanced alpha brain wave activity and increased synthesis of GABA. Greater GABA levels, in turn, increase the brain’s levels of dopamine and reduce serotonin levels, resulting in general feelings of calm and well-being.

Q: Does L Theanine boost immune system?

A: Previous studies have shown that L-theanine can enhance innate immune function by regulating the secretion of immune cytokines. Bukowski et al. [8] demonstrated that ingestion of L-theanine by drinking tea induces innate immune response and immunologic memory in humans.

12. Supplements containing L-theanine

  • NOW Supplements, L-Theanine 200 mg with Inositol, Stress Management*, 120 Veg Capsules
  • L-Theanine 200mg by Nature’s Trove – 120 Vegetarian Capsules
  • Nutricost L-Theanine 200mg, 120 Capsules – Double Strength
  • SOURCE NATURALS Serene Science L-Theanine 200 Mg Capsule, 120 Count
  • Country Life L-Theanine 200 mg – 60 Vegan Capsules – Gently Soothes Away The Tension – Helps Reduce Stress – Vitamin B-6
  • Solaray L-Theanine Chewable Supplement, 200 mg | 30 Count

13. Where you can buy L-theanine?

You can purchase L-theanine from China. MR Natural is a reliable supplier for high quality L-theanine. We supply it to Europe.

For L-theanine supplements, YOU can buy from online store like Amazon.

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