β−Nicotinamide mononucleotide / β-NMN

Product features in specifications:

Molecular Formula: C11H15N2O8P
Molecular Weight: 334.22
Appearance: White fine powder and crystalline powder

Bulk density: crystalline powder(0.5-0.7), White fine powder(0.15-0.25)
Purity: 99%
CAS NO.: 1094-61-7
EINECS No.: 214-136-5

Soluble: Water

Application: health products and cosmetic

Chemical Structure

Beta-Nicotinamide mononucleotide (NMN) is an intermediate of NAD+ biosynthesis produced from nicotinamide through nicotinamide phosphoribosyltransferase (NAMPT) and also referred to as NMN or nicotinamide ribotide. In recent studies of NMN applications to prevention and diagnosis of age-dependent diseases such as diabetes, neurodegenerative disorder, cardiac disease etc., it has become one of hottest biomarkers on discussion for anti-aging, lately. As one of worldwide leading manufacturers, we are now providing highly qualified fully physiologically active, beta-Nicotinamide mononucleotide (NMN) as to support basic research in not only Academia but also Pharmaceuticals.

What is NMN?

    Nicotinamide Mononucleotide (NMN) is an entirely natural compound found in our bodies and various food sources in minuscule amounts. Shown in animal studies an oral supplement of NMN showed increased liver NAD+ levels in just 10 minutes and showed an increase in muscle tissue by 30 minutes.

    Increased NAD+ levels activate anti-ageing pathways and restore genes back in to their youthful configuration, boosting energy metabolism, promoting healthy brain and cardiovascular function, repairing aged DNA and activating Sirtuins associated with longevity.

    NMN is the revolutionary new molecule used by Harvard Scientists to slow and even reverse the signs of ageing, that started the rush to NAD+ supplements.

• Boosts Cellular Energy Optimisation
• Promotes Healthy Brain and Cardiovascular Function 
• DNA Repair
• Sirtuin Activator

Scientists have now confirmed a direct link between falling NAD+ levels and ageing in both animals and human subjects. A breakthrough study published by Harvard scientists in 2013 showed for the first time that some aspects of ageing might be reversible. After treating old mice with NMN, several biometric markers that were subsequently measured resembled those of young mice: “the equivalent of a 60-year old converting to a 20-year old”. The research and understanding into NAD+ metabolomics are ongoing, but what the science has highlighted thus far, is the importance of supporting and maintaining our NAD+ levels.

There are currently several human clinical trials underway that are going to help answer this very question. Dr. Sinclair has been leading the charge in this field for years. Recent NMN trials in mice are very promising and show that more study is warranted. Watch the video below to hear what Dr. Sinclair has to say about where we are today.

A long-term evaluation of oral supplementation of NMN in mice was found to be effective at improving NAD+ levels safely. Mice supplemented with NMN vs. a control group showed notable age-associated differences in mass, energy metabolism, blood sugar, lipid metabolism, gene expression changes, mitochondrial oxygen use, eye function, bone density and immune function with no apparent toxic effects.

Curb the effects of aging by consuming NMN on a daily basis

NMN is found in breast milk and vegetables with high beta-carotene, such as broccoli, avocadoes, and green soybeans. However, the quantity found in these foods is extremely minimal. NMN is converted into NAD in the body, but this gradually decreases with age. In our late 50s, its quantity is nearly half of what it once was, and continues to decline thereafter. As a result, it becomes impossible to supplement it with food alone. Therefore, consuming NMN like a supplement is a means of curbing the onset of aging.

NMN content in food

*Amount currently consumed by humans in clinical studies of NMN

Cell Metab. 2016 Dec 13;24(6):795-806.

NMN content in raw milk

*Amount currently consumed by humans in clinical studies of NMN

Food Chem.2017 Apr 15;221:161-168

Mechanisms to suppressing aging and the role of NMN

Here we describe NAD, mitochondria, and sirtuin in order to help you better understand the mechanisms behind suppression of aging and the role played by NMN.

NMN

When consuming NMN through the mouth,
it passes through NMN transporters present on the cell surface and is absorbed into cells,
where it is converted into NAD.

NAD

NAD (nicotinamide adenine dinucleotide) can be found in the cells of every living organism,
and is the source of the body’s internal metabolism, being used whenever energy is produced.
However, NAD production begins to decrease in the body as we age.
Moreover, research has found that when consumed directly, NAD tends not to reach the cells,
so consuming NMN, a NAD precursor, is a more efficient means of delivering it to the body.
Attention is being drawn to NAD for its potential use in anti-aging using the two methods below.

Synthesis of energy (ATP) in the mitochondria

ATP refers to a source of energy that all living things use to survive. All eukaryotic cells and most archaebacteria and bacteria use NAD to synthesize ATP. NAD is essential to the synthesis of ATP; without it, living organisms die.

Sirtuin (SIRT) activation

The mechanisms behind aging hinge on an enzyme called sirtuin. This may be an unfamiliar term, but it is a protein that exists widely in organisms from bacteria to mammals, and plays a special role in controlling aging and lifespan. Humans possess a class of seven proteins called sirtuins that help control aging of the organs, but these sirtuins are normally dormant. NAD functions as a switch that acts on all seven of these sirtuins. In other words, as NAD declines through aging, the “switch” controlling sirtuins stops functioning, which is believed to contribute to decreased organ and tissue function.

Through NAD upregulation, NMN activates sirtuins to help curb aging.