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Soybean Extract Powder

soybean extract
Product name: soybean extract bulk powder
Latin name: Glycine max (Linn.) Merr.
Synonyms: soybean extract, soy isoflavones, soybean germ extract, glycine soja (soybean) germ extract,Glycine max (Linn.) Merr. soybean isoflavone extract
CAS number: 574-12-9
Molecular Formula: C15H10O4
Molecular Weight: 254.23
Specifications: Natural soy isoflavones 10%-90%, synthetic soy isoflavones 40%
Appearance/color: Light yellow fine powder
Benefits: Menopausal Symptoms(Especially for hot flash)
Application: food supplements
Dosage: 50-120mg/day
Bulk Package: 25KGS/drum, inner by double plastic bags Drum size:35cm*35cm*51cm N.W./G.W.: 25kgs/28kgs
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1. What is soybean extract powder?

Soybean extract is a kind of natural herbal extract. Using solvent to extract and concentrate the soybean to get active ingredient in the soybean.

Herbal extract is substance extracted from natural herb using different solvents like ethanol & water, pure water or other chemical solvent can draw out beneficial components from herb.

2. What is soy isoflavones?

Soy Isoflavones are one of the flavonoids, mainly found in legumes.

Soy isoflavones are a kind of phytoestrogens, also known as phytoestrogens, which are natural hormones.

Soy isoflavones are secondary metabolite formed during soybean growth.

Soy isoflavones mainly include: Daidzin, Daidzein, Genistin, Genistein, Glycitin, Glycitein.

daidzin structure
Daidzin
glycitin structure
glycitin
genistin structure
genistin
daidzein structure
Daidzein
glycitein structure
glycitein
genistein structure
genistein

3. Product origin

  • natural extract from soybean(Glycine max (Linn.) Merr.)
  • Synthetic

4. Basic physical and chemical properties

Product NameSoybean Extract/Soy Isoflavones
Other Namessoybean extract powder, soybean germ extract, glycine soja (soybean) germ extract, soybean isoflavone extract
Botanical sourceGlycine max (Linn.) Merr.
Origin of soybeanShandong province in China. Non-GMO soybean.
Part UsedSeed
Key IngredientSoy Isoflavones(genistin, daidzin, glycitin, genistein, daidzein, glycitein)
AppearanceLight yellow fine powder
Particle Size80mesh
SpecificationNatural soy isoflavones 10%-90%, synthetic soy isoflavones 40%
Recommended Dosage50-120mg/day.
Major benefitMenopausal Symptoms(Especially for hot flash)
Applicationin food supplement
CAS No. For soy isoflavones574-12-9
HS codeWe can export soybean extract with both following two HS code. 1302199099, to use this one, we need to do CIQ; 2932999099, to use this one, we don’t need to do CIQ. Fitting for small quantity shipping by courier.
Package25KGS/drum, inner by double plastic bags Drum size:35cm*35cm*51cm N.W./G.W.: 25kgs/28kgs
Shelf time2 years when properly stored

5. Certificate of analysis for soybean extract powder HPLC40% in three different types

a. Soy Isoflavones HPLC40% from 100% Natural Germ

ItemsMethodSpecificationsResults
Total isoflavonesHPLC≥40.00%41.25%
DaidzinHPLC 23.34%(Assay of daidzin is higher for extract from germ)
GlycitinHPLC 11.43%
GenistinHPLC 3.89%
DaidzeinHPLC 1.68%
GlyciteinHPLC 0.58%
GenisteinHPLC 0.33%
AppearanceVisual & tasteLight yellow powder with characteristic odor and tasteLight yellow powder with characteristic odor and taste
Loss on dryingGB/T 5009.3<5.0%2.60%
Sulphated ashGB/T 5009.4<5.0%2.80%
Bulk densityUSP <616>45.0~55.0g/100ml50.2g/100ml
Particle sizeUSP<786>100% through 80mesh100% through 80mesh
Heavy metalsGB/T 5009.741<10 ppmConform
ArsenicGB/T 5009.11<1 ppmConform
Total Plate CountGB/T 4789.2<1,000cfu/gConform
Yeasts & MoldsGB/T 4789.15<100cfu/gConform
E.coliGB/T 4789.3NegativeNegative
SalmonellaGB/T 4789.4NegativeNegative

b. Soy Isoflavones HPLC40% from 100% Natural beanpulp

ItemsMethodSpecificationsResults
Total isoflavonesHPLC≥40.00%41.01%
DaidzinHPLC 9.68%
GlycitinHPLC 2.99%
GenistinHPLC 27.50%(Asasy of Genistin is higher for extract from bean pulp)
DaidzeinHPLC 0.44%
GlyciteinHPLC 0.23%
GenisteinHPLC 0.16%
AppearanceVisual & tasteShallow Yellow powder with characteristic odor and tasteShallow Yellow powder with characteristic odor and taste
Loss on dryingGB/T 5009.3<5.0%2.9%
Sulphated ashGB/T 5009.4<5.0%2.9%
Bulk densityUSP <616>45.0~62.0g/100ml50g/100ml
Particle sizeUSP<786>100% through 80mesh100% through 80mesh
Heavy metalsGB/T 5009.741<20 ppmConform
ArsenicGB/T 5009.11<1 ppmConform
Total Plate CountGB/T 4789.2<1,000cfu/gConform
Yeasts & MoldsGB/T 4789.15<100cfu/gConform
E.coliGB/T 4789.3NegativeNegative
SalmonellaGB/T 4789.4NegativeNegative
StaphylococcusGB/T 4789.10NegativeNegative

c. Synthetic soy isoflavones

ItemsMethodSpecificationsResults
Total isoflavonesHPLC≥40.00%40.73%
DaidzinHPLC 3.42%
GlycitinHPLC 2.28%
GenistinHPLC 1.28%
DaidzeinHPLC 33.28%
GlyciteinHPLC 0.31%
GenisteinHPLC 0.16%
AppearanceVisual & tasteShallow Yellow powder with characteristic odor and tasteShallow Yellow powder with characteristic odor and taste
Loss on dryingGB/T 5009.3<5.0%2.60%
Sulphated ashGB/T 5009.4<5.0%2.80%
Bulk densityUSP <616>45.0~62.0g/100ml50g/100ml
Particle sizeUSP<786>100% through 80mesh100% through 80mesh
Heavy metalsGB/T 5009.741<20 ppmConform
ArsenicGB/T 5009.11<2 ppmConform
Total Plate CountGB/T 4789.2<1,000cfu/gConform
Yeasts & MoldsGB/T 4789.15<100cfu/gConform
E.coliGB/T 4789.3NegativeNegative
SalmonellaGB/T 4789.4NegativeNegative
StaphylococcusGB/T 4789.10NegativeNegative

6. How to produce soybean extract powder

40% soy isoflavone production flow

soy isoflavone production flow

7. Soybean extract powder benefits

a. Estrogen-like activity

Soy isoflavones can play estrogen-like or resist endogenous estrogen in the body, and can regulate estrogen receptors.

Soy isoflavones can improve perimenopausal syndrome.

Menopausal women taking soybean or soybean extract daily for more than 3 months, it can effectively reduce the frequency of hot flashes and significantly improve perimenopausal symptoms.

b. Antioxidant effect

The antioxidant effect of soybean isoflavones is mainly manifested in inhibiting the production of oxygen free radicals, inhibiting the production of hydrogen peroxide, reducing DNA oxidative damage and inhibiting lipid peroxidation.

c. Improve postmenopausal osteoporosis.

Soy isoflavones or metabolites show weak estrogen effects in postmenopausal women.

It binds to estrogen receptors in osteoblasts, strengthen the activity of osteoblasts, promote the production, secretion and bone mineralization process of bone matrix, thereby improving Osteoporosis.

d. Reduce the risk of breast cancer.

Soy isoflavones may reduce the risk of breast cancer by increasing the metabolism of estrogen to the anti-cancer product 2-hydroxyestrone.

It can also inhibit the occurrence and development of cancer by anti-oxidation, promoting cell apoptosis, and inhibiting cell proliferation.

e. Impact on the cardiovascular system.

The level of estrogen in postmenopausal women declines, leading to abnormal metabolism of fat and cholesterol.

And elevated blood lipids and cholesterol, leading to an increased incidence of cardiovascular disease. Soy isoflavones can prevent cardiovascular diseases through estrogen-like effects.

8. Soybean extract powder dosage

a. How to take soy isoflavones

Generally speaking, although there are many brands of soy isoflavones on the market, most of them are tablet and capsule.

The usage and dosage are different for different types. Among them, the usage of tablet soy isoflavones is relatively simple. You only need to take it every day. Take two tablets at a time, and soy isoflavone capsules only need to be taken once a day, taking 50mg at a time.

Different populations take different doses of soy isoflavones.

In addition, according to the understanding of female ovarian function decline, the dosage of soy isoflavones is also different for people of different age groups.

Women around 35 years old can start taking soy isoflavones.

Small doses are available before the age of 40.

During 41-50 years old sufficient dose should be used.

Large doses are needed after 50 years of age.

And the dose will be larger for women with symptoms of menopause.

Methods of taking soy isoflavones in different groups

  • Women over 40 years old without symptoms of menopause: take 50mg a day, intermittently;
  • Women over 50 years old without symptoms of menopause: take 50-100mg per day, continuously;
  • Women 35-40 years old with menopausal symptoms: 50mg per day for 2-3 months after the disappearance of menopausal symptoms;
  • Women 40-50 years old with menopausal symptoms: 100mg per day, after menopausal symptoms, reduce the dose to 50mg per day, and then take 2-3 months;
  • Women over 50 years of age with symptoms of menopause: 100mg per day, after menopause symptoms, reduce the dose to 100mg per day, and take it for 2-3 months;

In addition, if soy isoflavones are used in the treatment of certain diseases, such as breast cancer, endometrial cancer, prostate cancer, colon cancer, skin cancer, and leukemia, the amount of soy isoflavones taken by patients will be different.

And according to the health condition of each patient, even if the same disease is treated, the dose of soy isoflavones taken by the patient is not the same.

Tips:

Regardless of whether you are using soy isoflavones for health care or treatment of diseases, it is best to consult a relevant doctor first, and determine the correct way to take the drug under the doctor’s advice and guidance, and avoid taking it blindly. This is not only beneficial to health, health care, but also conducive to the treatment of diseases, and more conducive to avoid some adverse reactions after taking.

b. When is the best time to eat soy isoflavones?

For women, the best age for taking soy isoflavones should be over 35 years old, because the drug is not suitable for women who are too young, especially under-age women.

After such women taking soy isoflavones, it is easy to cause organs more active, leading to precocious puberty in underage women, which affects normal development.

c. When to take soy isoflavones?

The best time to take soy isoflavones is after meals.

The best time to take soy isoflavones is after meals, and the effect is best when taking after breakfast or dinner.

Because soy isoflavones are absorbed in the small intestine. The small intestine is working after eating, so soy isoflavones are more easily absorbed by the body.

Tips:

Whether soy isoflavones can be eaten for a long time is also a question that everyone is more concerned about.

In fact, soy isoflavones are still health-care drugs in the final analysis, so they can be taken for a long time.

However, you must follow the correct taking method, and avoid the contraindication of soy isoflavones, so that long-term use of the drug will not cause adverse reactions.

9. soybean extract powder side effects

As part of the soybean diet, soy isoflavones have been consumed by humans for many years and have high safety, but possible side effects or adverse reactions include gastrointestinal discomfort and nausea.

Severe allergies to soy-related products are rare.

However, if you experience any possible symptoms after eating, including: skin rash, itching/swelling (especially on the face, tongue, and throat), severe dizziness, and breathing difficulty, please seek medical assistance immediately.

Safety precautions (eight use taboo)

a. A study for the elderly found that a daily intake of 100 mg of soy isoflavones for 6 months showed good tolerance.

b. In vitro and animal studies have pointed out that for subjects with insufficient thyroid function or insufficient iodine intake, the intake of legumes may increase the risk of clinical hypothyroidism.

c. Do not use for pregnant women or breastfeeding women (because the relevant safety is unknown)

d. Although studies have shown that soy isoflavones can reduce breast cancer events and recurrence rates, women with a history of breast cancer, especially estrogen receptor positive (ER+) breast cancer patients, are best not to increase phytoestrogens taking, including soy isoflavones.

e. Although some studies have concluded that long-term high-dose soy isoflavones may stimulate endometrial hyperplasia, and endometrial hyperplasia may be related to endometrial cancer, this argument is still unproven.

f. People who have been allergic to soy products should not use it. Allergic reactions may occur.

g. Since isoflavone metabolism is related to intestinal bacteria, antibiotic treatment may reduce the bioavailability of isoflavones.

h. Do not use in combination with selective estrogen receptor modulators such as tamoxifen (an animal study found that high doses of soy isoflavones may interfere with the action of the drug).

10. Soybean extract powder safety

The US FDA recognizes soy isoflavones.

In 1999, the US FDA officially approved soy isoflavones as food to improve estrogen levels, and publicly published documents stating that soy isoflavones as a phytoestrogens supplement are very safe.

11. Soybean extract powder package & Notes for shipping

25kgs/drum, inner by double plastic bags.

N.W./G.W.: 25kgs/28kgs

Drum size: 37cm(diameter)*55cm(height)

Small order is accepted too. Such like 1kg/5kgs/10kgs.

Package for small quantity is by aluminium foil bag and carton box.

For 1-50kg, we suggest shipping by courier, such as DHL, fedex. HS code we use is 2932999099.

For 50-300kgs, we suggest shipping by air. HS code we use is 2932999099/1302199099.

For more than 300kgs, we suggest shipping by sea. HS code we use is 1302199099.

12. Soy isoflavones clinical trail

Effects of a standardized soy extract on hot flushes: a multicenter, double-blind, randomized, placebo-controlled study, link:https://pubmed.ncbi.nlm.nih.gov/12218721/

Soy isoflavones lower serum total and LDL cholesterol in humans: a meta-analysis of 11 randomized controlled trials, link:https://academic.oup.com/ajcn/article/85/4/1148/4648910

Soy isoflavones, estrogen therapy, and breast cancer risk: analysis and commentary, link:https://link.springer.com/article/10.1186/1475-2891-7-17

Soy isoflavone supplementation and bone mineral density in menopausal women: a 2-y multicenter clinical trial, link:https://academic.oup.com/ajcn/article/90/5/1433/4598177

Soy Isoflavones in the Prevention of Menopausal Bone Loss and Menopausal Symptoms A Randomized, Double-blind Trial, link:https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/1106084

Lycopene and Soy Isoflavones in the Treatment of Prostate Cancer, link: https://www.tandfonline.com/doi/abs/10.1080/01635580701413934

Effects of a high daily dose of soy isoflavones on DNA damage, apoptosis and estrogenic outcomes in healthy, postmenopausal women – a Phase I clinical trial, link:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574732/

Design and baseline characteristics of the Soy Phytoestrogens As Replacement Estrogen (SPARE) study — A clinical trial of the effects of soy isoflavones in menopausal women, link:https://www.sciencedirect.com/science/article/pii/S1551714410000376

Effects of soy isoflavones on mammographic density and breast parenchyma in postmenopausal women: a randomized, double-blind, placebo-controlled clinical trial, link: https://journals.lww.com/menopausejournal/Abstract/2013/10000/Effects_of_soy_isoflavones_on_mammographic_density.11.aspx

Skeletal benefits of soy isoflavones: a review of the clinical trial and epidemiologic data, link: https://journals.lww.com/co-clinicalnutrition/Abstract/2004/11000/Skeletal_benefits_of_soy_isoflavones__a_review_of.10.aspx

13. Extracts with similar functions:

Red clover extract with isoflavones

Black cohoshe extract

Related info:

a. Women’s Health: Are Menopause Supplements Effective?
By Judith C. Thalheimer, RD, LDN(https://www.todaysdietitian.com/newarchives/0316p18.shtml)

b. Menopause Supplements Review (Soy and Red Clover Isoflavones, Black Cohosh) and Progesterone Creams(https://www.consumerlab.com/reviews/soy-isoflavones-red-clover-black-cohosh-supplements/phytoestrogens/)

14. Supplements containing soybean extract powder

  • GNC Jiananxi concentrated soy isoflavone capsules
  • Swanson Swanson Soy Isoflavones 15mg*60 Capsules
  • Now Foods Soy Isoflavones 120 Veg Capsules
  • Nature’s Way Soy Isoflavones – 100 Capsule
  • Super Absorbable Soy Isoflavones 60 Vegetarian Capsules by Life Extension

15. Where to buy?

You can purchase soybean extract powder(with soy isoflavones as a key ingredient) from China. MR Natural is a reliable soybean extract manufacturer in China. We supply it to Japan and Europe.

For soy supplement, YOU can buy from online store like Amazon, JD, Taobao.

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